J Neurogastroenterol Motil.  2013 Oct;19(4):433-453.

Abdominal Bloating: Pathophysiology and Treatment

Affiliations
  • 1Department of Internal Medicine, Seoul National University, Bundang Hospital, Seongnam, Gyeonggi-do, Korea. nayoungkim49@empas.com
  • 2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Abdominal bloating is a very common and troublesome symptom of all ages, but it has not been fully understood to date. Bloating is usually associated with functional gastrointestinal disorders or organic diseases, but it may also appear alone. The pathophysiology of bloating remains ambiguous, although some evidences support the potential mechanisms, including gut hypersensitivity, impaired gas handling, altered gut microbiota, and abnormal abdominal-phrenic reflexes. Owing to the insufficient understanding of these mechanisms, the available therapeutic options are limited. However, medical treatment with some prokinetics, rifaximin, lubiprostone and linaclotide could be considered in the treatment of bloating. In addition, dietary intervention is important in relieving symptom in patients with bloating.

Keyword

Bloating; Pathophysiology; Rifaximin; Therapy

MeSH Terms

Alprostadil
Gastrointestinal Diseases
Humans
Hypersensitivity
Metagenome
Peptides
Reflex
Rifamycins
Lubiprostone
Alprostadil
Peptides
Rifamycins
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