J Korean Soc Pediatr Endocrinol.
2009 Dec;14(2):94-99.
Insulin Resistance and Intracellular Thyroid Hormone Dysfunction
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- 1Department of pediatrics, Chosun Medical School, Gwangju, Korea. sskey@chosun.ac.kr
Abstract
- Insulin resistance and diabetes combine to impair mitochondrial oxidative metabolism and cause lipid accumulation in non-adipose tissues such as skeletal muscles and the liver. The thyroid hormone stimulates thermogenesis, mitochondrial biogenesis, and various metabolisms, including gluconeogenesis and fatty-acid oxidation. Therefore, altered thyroid hormone action may induce the mitochondrial phenotype associated with insulin resistance. This review focuses on the correlation between thyroid hormone function and diabetes and the possible mechanisms associated with intracellular thyroid hormone dysfunction due to impaired metabolism.
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