J Korean Soc Pediatr Endocrinol.  2008 Jun;13(1):104-109.

Three Cases of Polycystic Ovary Syndrome Presenting with Hirsutism and Obesity in Adolescence

• Lee SH
• Ko JM
• Yoo HW

Abstract

Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism. It is a complex disorder with multiple components, including infertility, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular diseases. We report three cases of PCOS presenting with hirsutism and obesity in adolescence. They showed hirsutism, acne and acanthosis nigricans, and obesity with the body mass index above the ninety-fifth percentile for their age and sex matched reference values. Laboratory findings showed elevated luteinizing hormone, total testosterone and decreased sex hormone binding globulin. One patient was diagnosed as having impaired glucose tolerance by oral glucose tolerance test, and three patients showed insulin resistance classified by homeostasis model assessment-insulin resistance (HOMA-IR) value. All patients were treated with exercise, low calorie diet. And metformin and estrogen- progesterone oral contraceptives were administered in two of three patients, respectively. During the follow-up period, two patients have achieved weight loss and recovered regular menstruation.

Keyword

Polycystic ovary syndrome; Hirsutism; Obesity; Adolescent

MeSH Terms

Acanthosis Nigricans
Acne Vulgaris
Adolescent
Body Mass Index
Caloric Restriction
Cardiovascular Diseases
Contraceptives, Oral
Diabetes Mellitus, Type 2
Female
Follow-Up Studies
Glucose
Glucose Tolerance Test
Hirsutism
Homeostasis
Humans
Hyperandrogenism
Infertility
Insulin Resistance
Luteinizing Hormone
Metformin
Obesity
Ovary
Polycystic Ovary Syndrome
Progesterone
Reference Values
Sex Hormone-Binding Globulin
Testosterone
Weight Loss
Contraceptives, Oral
Glucose
Luteinizing Hormone
Metformin
Progesterone
Sex Hormone-Binding Globulin
Testosterone