J Korean Acad Periodontol.  2009 Aug;39(Suppl):287-291.

Clinical presentation of a horse-derived biomaterial and its Biocompatibility: A Clinical Case Report

• Koo KT
• Park JY
• Park JS
• Kim TI
• Seol YJ
• Lee YM
• Ku Y
• Rhyu IC
• Chung CP

Abstract

PURPOSE: The objective of this clinical presentation was to present a clinical case series report of socket preservation, sinus augmentation, and bone grafting using a horse-derived biomaterial.
METHODS
A horse-derived biomaterial was used in 8 patients for different indications including socket preservation following tooth extraction, osseous bone grafting, and sinus augementation procedures. Surgeries were performed by a well trained specialist and clinical radiographs were obtained at designated intervals. Biopsy cores of 2 x 8 mm prior to implant placement was obtained following a healing interval of 4 - 6 months. A clinical and histologic evaluation was performed to evaluate the clinical effectiveness and biocompatibility of the biomaterial.
RESULTS
All surgeries in 8 patients were successful with uneventful healing except for one case with membrane exposure that eventually resulted with a positive outcome. Radiographic display of the healing phase during different intervals showed increased radiopacity of granular nature as the healing time increased. No signs of adverse effect or infection was observed clinically and the tissues surrounding the biomaterial seemed well-tolerated with good intentional healing. The augmented sinuses healed uneventfully suggesting in part, good biocompatibility of the biomaterial. Dental implants placed following socket preservation were inserted with high initial torque suggesting good initial stability and bone quality.
CONCLUSIONS
Our results show that at least on a tentative level, a horse-derived biomaterial may be used clinically in socket preservation, sinus augmentation, bone grafting techniques with good intentional healing and positive results.

Keyword

biocompatible materials; bone substitutes; wound healing

MeSH Terms

Biocompatible Materials
Biopsy
Bone Substitutes
Bone Transplantation
Dental Implants
Humans
Membranes
Specialization
Tooth Extraction
Torque
Wound Healing
Biocompatible Materials
Bone Substitutes
Dental Implants

Figure

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  Figure 1 Clinical illustration of the maxillary right premolar region grafted with a horse-derived bone substitute and a collagen membrane following extraction of the second premolar. A.clinical photograph prior to extraction (×2) B.extraction socket following extraction of the second premolar (×2) C.adaptaion of the collagen membrane to the extraction site (×2) D.clinical photograph following the graft procedure (×2) E.clincal photograph after suturing F.clinical photograph following suture removal at 1 week (×2).

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  Figure 2 Radiographs illustrating the grafted extraction socket site from pre-extraction to implant placement at 6 months. A.maxillary right second premolar before extraction B.radiographic representation of the site grafted with OCS-H at 1 month post-surgery C.healing at 3 months post-surgery D.healing at 6 months post-surgery E. 3 dental implants were placed successfully in the extraction socket site grafted with OCS-H after 6 months F. contralateral side also grafted with OCS-H following tooth extraction.

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  Figure 3 Photomicrograph of a 2×8 mm biopsy core obtained prior to implant placement. (basic fuchsin & methylene blue staining, Original magnification ×20).

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  Figure 4 Clinical photograph and radiograph illustrating a severely pneumatized maxillary sinus grafted with OCS-H.

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  Figure 5 Clinical and radiographic presentation grafting procedure with a horse-derived bone substitute on the maxillary second molar region. A.clinical photograph of the region prior to grafting (×2) B.a membrane was secured using the buccal and palatal flaps (×2) C.an attempt was made to achieve good primary intentional healing (×2) D.panoramic view of the right maxillary second molar region prior to extraction E.radiograph taken at 2 weeks post-op F.radioghic presentation of the grafted area at 6 months.

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