J Korean Acad Oral Health.  2014 Mar;38(1):3-9.

Comparison of the whitening effect of toothpastes containing 0.25% hydroxyapatite and 0.75% hydrogen peroxide

  • 1Department of Preventive Dentistry, Kyungpook National University School of Dentistry, Daegu, Korea. cyh1001@knu.ac.kr
  • 2Faculty of Health Science, Daegu Haany University, Gyeongsan, Korea.
  • 3Department of Dental Hygiene, Masan University, Changwon, Korea.
  • 4Department of Dental Hygiene, Choonhae College of Health Sciences, Ulsan, Korea.


The aim of this study was to compare the tooth bleaching effect of two whitening materials in toothpaste i.e., hydroxyapatite and hydrogen peroxide on. In a randomized, double blinded controlled clinical trial, 85 participants with tooth colorations were assigned to use one of three toothpastes containing either hydroxyapatite (0.25%), hydrogen peroxide (0.75%), or no active ingredient (placebo). The patients were examined at baseline and 1, 2, and 3 months after usage.
The patients underwent an oral examination, tooth shade measurement, and a subjective evaluation. During the oral examination, the patient's oral health status was determined. ShadeEye NCC and Vita classical shade guide were used to determine the tooth color. Further, the patients were asked to assess the color of their own teeth using a visual analog scale (VAS) scale (range, 1-5).
According to the CIELAB system, a significantly greater color change (Deltab*) was observed in the hydrogen peroxide group (2.10+/-1.54) than in the hydroxyapatite (1.50+/-1.09) and control (0.94+/-0.75) groups after 3 months of toothpaste usage (P<0.002). The DeltaE*color change was not statistically significant among the 3 groups at each time point (P>0.05). The subjective evaluation results of the hydroxyapatite (P=0.023) and hydrogen peroxide (P=0.047) groups were statistically significant at each time point.
The hydrogen peroxide-containing toothpaste caused significant lightening of tooth coloration than the hydroxyapatite and placebo toothpastes.


Hydrogen peroxide; Hydroxyapatite; Tooth bleaching; Tooth shade; Whitening toothpaste
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