J Korean Acad Oral Health.  2013 Dec;37(4):175-179.

Polycan-calcium gluconate complex improves gingival health

  • 1Department of Preventive Dentistry, Kyungpook National University School of Dentistry, Daegu, Korea. kbsong@knu.ac.kr
  • 2Department of Oral Biochemistry, Kyungpook National University School of Dentistry, Daegu, Korea.


OBJECTIVES: The aim of this study was to examine the effect of a Polycan-calcium gluconate complex on gingival health.
Forty-one subjects with mild periodontitis (> or =40 years) were divided into two groups: the placebo and test product (Polycan-calcium gluconate complex twice a day for 4 weeks) groups. Oral examination was performed and gingival crevicular fluid (GCF) was collected from each subject at baseline and after 4 weeks. Interleukin (IL)-1beta level in the GCF was determined using enzyme-linked immunosorbent assay.
Pocket depth and plaque index were significantly decreased in the test group at 4 weeks. The level of IL-1beta and plaque index of the treatment group was significantly lower than of the placebo group.
Based on the above results, Polycan-calcium gluconate complex may inhibit plaque accumulation in the mouth and may have a negative correlation with the level of inflammatory biomarkers. Consequently, gingival health was significantly improved by polycan-calcium gluconate complex.


beta-glucan; Calcium gluconate; Gingival health; Polycan
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