Yeungnam Univ J Med.
2007 Jun;24(1):85-90.
Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
- 2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea. chscp@med.yu.ac.kr
Abstract
- According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment . This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).
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