Urogenit Tract Infect.  2016 Apr;11(1):17-24. 10.14777/uti.2016.11.1.17.

Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study

  • 1Department of Urology, Chonnam National University Medical School, Gwangju, Korea. drjsi@yahoo.co.kr
  • 2Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
  • 3Department of Urology, Chung-Ang University School of Medicine, Seoul, Korea.
  • 4Department of Urology, Ewha Womans University School of Medicine, Seoul, Korea.
  • 5Department of Urology, Jeju National University School of Medicine, Jeju, Korea.
  • 6Department of Urology, Chosun University School of Medicine, Gwangju, Korea.
  • 7Department of Urology, National Police Hospital, Seoul, Korea.
  • 8Department of Urology, Dankook University Medical College, Cheonan, Korea.
  • 9Department of Urology, Dongguk University School of Medicine, Gyeongju, Korea.
  • 10Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea.
  • 11Department of Urology, Myongji Hospital, Seonam University, Goyang, Korea.
  • 12Department of Urology, Veterans Health Service Medical Center, Seoul, Korea.
  • 13Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 14Department of Urology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
  • 15Department of Urology, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea.
  • 16Department of Urology, Konkuk University School of Medicine, Chungju, Korea.
  • 17Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
  • 18Department of Urology, Kwangju Christian Hospital, Gwangju, Korea.
  • 19Department of Urology, Soon Chun Hyang University Bucheon Hospital, Bucheon, Korea.
  • 20Department of Urology, Dong-A University College of Medicine, Busan, Korea.
  • 21Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
  • 22Department of Urology, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Korea.
  • 23Department of Urology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
  • 24Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea.


Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.
A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroquinolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidone-iodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.
The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).
The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy.


Biopsy; Escherichia coli; Fluoroquinolones; Infection; Prostate

MeSH Terms

Anti-Bacterial Agents
Antibiotic Prophylaxis
Escherichia coli
Odds Ratio
Prospective Studies*
Risk Factors
Anti-Bacterial Agents
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