Tuberc Respir Dis.
2005 Nov;59(5):517-521.
Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Inha University, Incheon, Republic of Korea. jaehwa.cho@inha.ac.kr
- 2Department of Clinical Pathology, College of Medicine, Inha University, Incheon, Republic of Korea.
Abstract
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BACKGROUND: The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions.
METHODS
The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay.
RESULTS
The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates.
CONCLUSION
Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.
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