Tuberc Respir Dis.  1996 Feb;43(1):54-62.

Usefulness of 99mTx Methoxyisobutylisonitrile Lung SPECT in Benign andMalignant Lesion of the Lungs

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Yeungnam University, Taegu, Korea.
  • 2Department of Nuclear Medicine, College of Medicine, Yeungnam University, Taegu, Korea.
  • 3Department of Pathology, College of Medicine, Yeungnam University, Taegu, Korea.

Abstract

BACKGROUND
99mTc MIBI(Methoxyisobutylisonitrile complex), a member of the isonitrile class of coordination compounds, is a lipophilic cation presently under investigation for clinical use as myocardial perfusion imaging agent and is widely used to detect myocardial infarction. Preliminary reports indicate that T1-201 accumulate in human neoplasm and several authors reported 99mTc MIBI may also localized in primary malignant tumor and metastatic deposits from lung cancer. We evaluated the uptake of 99mTc MIBI in lung cancer and localization of mediastinal and other site metastasis, and compared the benign lesion of the lung. METHOD: Thirty four patients of lung cancer and ten patients of benign lung lesion were studied with chest CT and 99mTc MIBI Lung SPECT. 99mTc MIBI uptake ratio was assessed by TR/NL(Lung lesion/ Normal area), HT/NL (Heart/ Normal area) and HT/TR(Heart/Lung lesion).
RESULTS
1) All lung cancer patients showed increased uptakes of 99mTc MIBI in malignant lung lesion and Tc-99m MIBI uptake was also increased in mediastinal and lymph node metastasis except two cases. 2) There was significant different ratio of TR/NL between malignant and benign lesion, 3.79 +/- 1.82 and 1.67+/-0.63 on planar images, respectively(p <0.001). 3) There was no significant difference of 99mTc MIBI uptake ratio between squamous cell carcinoma, small cell carcinoma and adeno carcinoma(3.64+/- 1.66, 3.57+/-0.72, 4.31 +/-2.28 respectively).
CONCLUSION
99mTc MIBI lung SPECT was useful in the localization of tumor and mediastinal or other site metastatic lesion in lung cancer and also in the differential diagnosis between benign and malignant lesion.

Keyword

99mTc MIBI lung SPECT; Lung cancer

MeSH Terms

Carcinoma, Small Cell
Carcinoma, Squamous Cell
Diagnosis, Differential
Humans
Lung Neoplasms
Lung*
Lymph Nodes
Myocardial Infarction
Myocardial Perfusion Imaging
Neoplasm Metastasis
Tomography, Emission-Computed, Single-Photon*
Tomography, X-Ray Computed
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