Soonchunhyang Med Sci.  2014 Dec;20(2):163-167. 10.0000/sms.2014.20.2.163.

Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury

Affiliations
  • 1Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. hkpark@schmc.ac.kr
  • 2Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Abstract

Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and American management guidelines for hyperthyroidism, mehimazole is recommended as the first-choice antithyroid drug for the treatment of hyperthyroidism. Toxic hepatitis rarely occurs in methimazole users. We report a rare case of a 52-year-old female with toxic hepatitis after methimazole use that had past medical history of simvastatin induced liver injury.

Keyword

Methimazole; Simvastatin; Drug-induced liver injury; Drug interactions

MeSH Terms

Drug Interactions
Drug-Induced Liver Injury
Female
Hepatitis*
Humans
Hyperthyroidism
Liver*
Methimazole
Middle Aged
Simvastatin
Methimazole
Simvastatin
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