Sleep Med Psychophysiol.  1997 Jun;4(1):89-95.

Successful Treatment of Five Cases of Idiopathic Central Nervous System Hypersomnia

• Yoon IY
• Jeong DU

Abstract

The authors studied 5 cases of idiopathic CNS hypersomnia who visited Division of Sleep Studies, Seoul National University Hospital in 1995. Detailed medical history was taken and nocturnal polysomnography(NPSG), multiple sleep latency test(MSLT)and human leukocyte antigen(HLA) typing were performed. Neither cataplexy nor hypnagogic hallucination was reported in all cases and in NPSGs, there were tendencies of increased sleep period time and decreased slow wave sleep time. In MSLT, all the subjects showed average sleep latencies less than 8 minutes without sleep-onset rapid eye movement period(SOREMP). In HLA typing, some correlation between idiopathis CNS hypersomnia and HLA DR4 was observed. in contrast to previous reports, overall treatment response with methylphenidate was remarkable. Therefore, the authors suggest that patients suspected of idiopathic CNS hypersomnia be actively evaluated and treated with rather optimistic perspective.

Keyword

Idiopathic central nervous system hypersomnia; Human leukocyte antigen; Methylphenidate

MeSH Terms

Cataplexy
Central Nervous System*
Disorders of Excessive Somnolence*
Hallucinations
Histocompatibility Testing
Humans
Leukocytes
Methylphenidate
Seoul
Sleep, REM
Methylphenidate