Psychiatry Investig.
2011 Dec;8(4):372-376.
Electroencephalographic Abnormalities in Clozapine-Treated Patients: A Cross-Sectional Study
- Affiliations
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- 1Senior Resident, Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
- 2Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India. samirpsyche@yahoo.co.in
- 3Consultant Child and Adolescent Psychiatrist, Oxfordshire and Buckinghamshire Mental Health NHS Foundation Trust, Boundary Brook House (Park Hospital), Churchill Drive, Headington, Oxford, OX3 7LQ, UK.
- 4Professor of Psychiatry, In Charge Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
Abstract
- The objective of our study was to examine the electroencephalogram (EEG) abnormalities associated with clozapine treatment. It was a cross-sectional study on 87 psychiatric patients on clozapine treatment. 32 channel digital EEG was recorded and analysed visually for abnormalities. EEG abnormalities were observed in 63.2% of patients. Both slowing and epileptiform activities were noted in 41.4% of patients. The EEG abnormalities were not associated with dose or duration of clozapine exposure.
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