Psychiatry Investig.  2011 Dec;8(4):366-371.

Transferrin In Korean Children With Attention Deficit Hyperactivity Disorder

Affiliations
  • 1Environmental Health Center, Dankook University Hospital, Cheonan, Korea. paperose@dku.edu
  • 2Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, Korea.
  • 3Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea.
  • 4Department of Laboratory Medicine, College of Medicine, Dankook University, Cheonan, Korea.

Abstract


OBJECTIVE
The aim of the present study was to investigate the relationship between iron, ferritin, transferrin, total iron binding capacity (TIBC), hemoglobin, mean corpuscular volume (MCV) mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in children with ADHD.
METHODS
MethodsaaThe sample consisted of 48 ADHD children and sex and age matched control children (a couple of 28 boys, 22 girls; age 6-8 years; mean+/-SD, 6.98+/-0.39). We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated subjectively with Conners' Parent Rating Scales, Dupaul Parent ADHD Rating Scales. Subjects with ADHD and control were evaluated the hematology test including the iron, transferrin, MCV etc. Paired t test were used to evaluate the relation of a lot of hematology findings between ADHD and control group.
RESULTS
The serum iron, ferritin, transferrin, TIBC, hemoglobin, MCV, MCH, and MCHC of ADHD group were respectively 80.92+/-33.33 ug/dL, 35.81+/-16.59 ng/mL, 248.42+/-44.15 mg/dL, 351.69+/-102.13 ug/dL, 12.78+/-0.71 g/dL, 82.94+/-2.58 fL, 27.18+/-1.12 uug, 32.79+/-1.12%. Otherwise the serum iron, ferritin, transferrin, TIBC, hemoglobin, MCV, MCH, and MCHC of control group were respectively 82.04+/-28.14 ug/dL, 37.05+/-18.28 ng/mL, 266.27+/-25.40 mg/dL, 352.77+/-89.54 ug/dL, 12.77+/-0.70 g/dL, 81.81+/-2.96 fL, 26.69+/-0.99 uug, 32.66+/-0.96%. A significant difference were found in the transferrin(t=2.63, p=0.011), MCV (t=2.19, p=0.034), and MCH (t=2.18, p=0.034).
CONCLUSION
These results suggested that lower transferrin levels might be related with ADHD symptoms.

Keyword

ADHD; Transferrin; Hematology; Child
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