Psychiatry Investig.
2009 Dec;6(4):313-315.
Resolution of Pregabalin and Mirtazapine Associated Restless Legs Syndrome by Bupropion in a Patient with Major Depressive Disorder
- Affiliations
-
- 1Department of Neuropsychiatry, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea. medipark@hanmail.net
- 2Department of Psychiatry, Anam Hosipital, Korea University College of Medicine, Seoul, Korea.
- 3Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, Korea.
Abstract
- Bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, and is therefore an antidepressant with unique pharmacological properties. There are some reports that selective serotonin reuptake inhibitors (SSRIs) or mirtazapine can induce adverse effects including restless legs syndrome (RLS) and that bupropion can reverse these adverse effects. Here, we report about a patient with a major depressive disorder who exhibited RLS after being treated with pregabalin and mirtazapine. This adverse effect disappeared after having switched from mirtazapine to bupropion. Bupropion inhibits the reuptake of dopamine and increases dopamine neurotransmission in both the nucleus accumbens and the prefrontal cortex. This pharmacological profile can be effective in patients with RLS related to dopamine hypoactivity. However, the limitations of this single case report mean that further investigations with larger samples are needed.
Keyword
MeSH Terms
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Restless Leg Syndrome Induced by Mirtazapine in a Patient with Major Depressive Disorder
- A Case of Mirtazapine Induced Restless Legs Syndrome
- A Single Low Dose of Mirtazapine can Induce Restless Legs Syndrome: Report of Two Cases
- A Case of Restless Leg Syndrome Induced by Bupropion in a Patient with Bipolar Disorder
- Updates on the Treatment of Restless Legs Syndrome
