Psychiatry Investig.  2008 Sep;5(3):193-198.

Serum S100B Levels and Major Depressive Disorder: Its Characteristics and Role in Antidepressant Response

Affiliations
  • 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
  • 2Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea.

Abstract


OBJECTIVE
S100B is a neurotrophic factor that is involved in neuroplasticity. Neuroplasticity is disrupted in depression; however, treatment with antidepressants can restore neuroplasticity. S100B has previously been used as a biological marker for neuropathology and neuroplasticity; therefore, in this study, we compared serum S100B levels in depressive patients to those of normal controls. In addition, we compared the serum S100B levels of antidepressant responders to those of nonresponders.
METHODS
Thirty five normal controls and 59 depressive patients were enrolled in this study. Depressive patients entered a 6 week clinical trial that included treatment with antidepressants. The serum S100B levels and clinical assessments, which included Hamilton depression rating scores, were measured at baseline and after 6 weeks of treatment with antidepressants. The difference in the serum S100B levels between depressive patients and normal controls and between antidepressant responders and nonresponders was then compared.
RESULTS
There were no significant differences in the serum S100B levels of normal controls and depressive patients. In addition, 30 of the depressive patients responded to antidepressant treatment while 29 did not. Finally, the responders had significantly higher baseline serum S100B levels than the nonresponders.
CONCLUSION
The results of this study suggest that the baseline serum S100B level is associated with the subsequent response to antidepressants. In addition, the high baseline serum S100B level that was observed in depressive patients may enhance neuroplasticity, which results in a favorable therapeutic response to antidepressants.

Keyword

S100B; Major depressive disorder; Antidepressant; Response; Neuroplasticity

MeSH Terms

Antidepressive Agents
Biomarkers
Depression
Depressive Disorder, Major*
Humans
Neuronal Plasticity
Antidepressive Agents
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