Korean J Urol.  2012 Aug;53(8):552-555.

Analysis of Changes in the Glomerular Filtration Rate as Measured by the Cockroft-Gault Formula in the Early Period after Percutaneous Nephrolithotomy

Affiliations
  • 1Department of Urology, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey. Dromerbayrak@yahoo.com

Abstract

PURPOSE
We aimed to analyze the changes in kidney function during the postoperative early period caused by the application of percutaneous nephrolithotomy (PNL), which is commonly used in kidney stone surgery.
MATERIALS AND METHODS
PNL was performed in 80 patients (48 men, 32 women) with kidney stones. The mean age of the patients was 43.71 years (range, 18 to 71 years). Preoperative and postoperative values for stone size, glomerular filtration rate (GFR), serum creatinine, urea, electrolytes (Na, K, Cl), and Hb were compared in 80 patients in whom PNL surgery was performed. The formula of Cockroft-Gault was used to calculate the GFR during the early postoperative period (72 to 96 hours).
RESULTS
Statistically significant decreases after PNL were observed in average stone size (preoperative, 627.75+/-375.10 mm2; postoperative, 81.70+/-16.15 mm2), serum urea (preoperative, 38.40+/-17.26 mg/dl; postoperative, 33.28+/-16.98 mg/dl), and creatinine (preoperative, 1.03+/-0.53 mg/dl; postoperative, 0.97+/-0.55 mg/dl) and an increase was observed in GFR (preoperative, 104.30+/-37.30 ml/min; postoperative, 112.38+/-40.1 ml/min). No changes were detected in the serum electrolyte values (Na, K, Cl). Multiple access, operation time, and type of lithotripter did not have any significant effects on the change in the GFR.
CONCLUSIONS
In light of our results, PNL for kidney stone operations appears to be a reliable and efficient method that provides recovery of kidney functions in the early post-operative period by increasing the GFR and with high stone-free rates.

Keyword

Glomerular filtration rate; Nephrolithiasis; Percutaneous nephrostomy

MeSH Terms

Creatinine
Electrolytes
Glomerular Filtration Rate
Humans
Kidney
Kidney Calculi
Light
Male
Nephrolithiasis
Nephrostomy, Percutaneous
Postoperative Period
Urea
Creatinine
Electrolytes
Urea

Reference

1. Pearle MS, Lotan Y. Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Urinary lithiasis: etiology, epidemiology, and pathogenesis. Campbell-Walsh urology. 2007. 9th ed. Philadelphia: Saunders Company;1386–1387.
2. Fernstrom I, Johansson B. Percutaneous pyelolithotomy. A new extraction technique. Scand J Urol Nephrol. 1976. 10:257–259.
3. Liou LS, Streem SB. Long-term renal functional effects of shock wave lithotripsy, percutaneous nephrolithotomy and combination therapy: a comparative study of patients with solitary kidney. J Urol. 2001. 166:36.
4. Parsons JK, Jarrett TW, Lancini V, Kavoussi LR. Infundibular stenosis after percutaneous nephrolithotomy. J Urol. 2002. 167:35–38.
5. Nouralizadeh A, Sichani MM, Kashi AH. Impacts of percutaneous nephrolithotomy on the estimated glomerular filtration rate during the first few days after surgery. Urol Res. 2011. 39:129–133.
6. Aridogan IA, Bayazit Y. Percutaneous surgery in renal stone disease. Turkiye Klinikleri J Urol-Spec Top. 2009. 2:66–70.
7. Canes D, Hegarty NJ, Kamoi K, Haber GP, Berger A, Aron M, et al. Functional outcomes following percutaneous surgery in the solitary kidney. J Urol. 2009. 181:154–160.
8. Marberger M, Stackl W, Hruby W, Kroiss A. Late sequelae of ultrasonic lithotripsy of renal calculi. J Urol. 1985. 133:170–173.
9. Moskovitz B, Halachmi S, Sopov V, Burbara J, Horev N, Groshar D, et al. Effect of percutaneous nephrolithotripsy on renal function: assessment with quantitative SPECT of (99m)Tc-DMSA renal scintigraphy. J Endourol. 2006. 20:102–106.
10. Handa RK, Matlaga BR, Connors BA, Ying J, Paterson RF, Kuo RL, et al. Acute effects of percutaneous tract dilation on renal function and structure. J Endourol. 2006. 20:1030–1040.
11. Handa RK, Evan AP, Willis LR, Johnson CD, Connors BA, Gao S, et al. Renal functional effects of multiple-tract percutaneous access. J Endourol. 2009. 23:1951–1956.
Full Text Links
  • KJU
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr