Korean J Urol.  2012 May;53(5):368-370.

Seminal Vesicle Involvement by Urothelial Carcinoma in Situ of the Bladder with Mucosal Spread Pattern: A Case Report

• Choi SY
• Lee HC
• Song HG
• Kim WJ
• Lee OJ

Abstract

Mucosal spreading of urothelial tumors to the seminal vesicles is very rare. We experienced a case of mucosal involvement of the seminal vesicles by a bladder tumor in a 72-year-old man. The patient had a history of transurethral resection for invasive urothelial carcinoma of the bladder 8 years previously. Radical cystoprostatectomy was performed owing to recurrent and multiple urothelial carcinoma in situ. Microscopically, the urothelial carcinoma in situ was throughout the mucosa of the urinary bladder, both ureters, the prostate, and the left seminal vesicle. To date, the implication of mucosal involvement of the seminal vesicles by urothelial carcinoma is unclear. However, careful microscopic examination is needed to avoid an erroneous diagnosis.

Keyword

Carcinoma in situ; Seminal vesicles; Urinary bladder neoplasms

MeSH Terms

Aged
Carcinoma in Situ
Humans
Mucous Membrane
Prostate
Seminal Vesicles
Ureter
Urinary Bladder
Urinary Bladder Neoplasms

Figure

• 

  FIG. 1 (A) Urothelial carcinoma in situ is observed in the urinary bladder, which epithelium is covered by the proliferating large tumor cells with hyperchromatic nuclei (H&E, ×200). (B) The mucosa of the seminal vesicle shows pagetoid spread of the tumor cells. The tumor cells infiltrate between the epithelial cells of the seminal vesicle (arrow) and the basal lamina (H&E, ×200). (C) A focus of the ejaculatory duct (arrow) and (D) the prostatic acini and ducts (arrow) are also involved by tumor cells (C, H&E, ×40; D, H&E, ×100).

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