Korean J Urol.  2012 May;53(5):297-303.

High-Grade Prostatic Intraepithelial Neoplasia

Affiliations
  • 1Glickman Urologic and Kidney Institute, Cleveland, Ohio, USA. klinkj@ccf.org

Abstract

High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.

Keyword

HGPIN; High grade prostatic intraepithelial neoplasia; Prostate biopsy; Prostate cancer

MeSH Terms

Adenocarcinoma
Biopsy
Mass Screening
Prostate
Prostate-Specific Antigen
Prostatic Intraepithelial Neoplasia
Prostatic Neoplasms
Prostate-Specific Antigen
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