Pediatr Gastroenterol Hepatol Nutr.  2015 Jun;18(2):144-148. 10.5223/pghn.2015.18.2.144.

Atypical beta-Catenin Activated Child Hepatocellular Tumor

Affiliations
  • 1Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. aturanrad@gmail.com
  • 2Department of Radiology, Ankara Pediatric Hematology and Oncology Training and Research Hospital, Ankara, Turkey.
  • 3Department of Patology, Ankara Pediatric Hematology and Oncology Training and Research Hospital, Ankara, Turkey.
  • 4Department of Pediatrics, Ankara Pediatric Hematology and Oncology Training and Research Hospital, Ankara, Turkey.
  • 5Department of Radiology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.

Abstract

Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The beta-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of beta-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-1alpha-inactivated hepatocellular adenomas subtype, has not been previously reported in any beta-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

Keyword

Adenoma; Liver; Hepatocellular carcinoma; Magnetic resonance imaging; Beta-catenin

MeSH Terms

Adenoma
Adenoma, Liver Cell
beta Catenin*
Carcinoma, Hepatocellular
Child*
Hepatocytes
Humans
Liver
Liver Neoplasms
Magnetic Resonance Imaging
beta Catenin
Full Text Links
  • PGHN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr