Pediatr Allergy Respir Dis.  2012 Dec;22(4):397-403.

A Clinical Approach of Post-Infectious Bronchiolitis Obliterans Using the Results of High Resolution Computed Tomography

Affiliations
  • 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. kekim@yumc.yonsei.ac.kr
  • 2Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
Bronchiolitis obliterans (BO) is a type of chronic obstructive lung disease. In children, the most common presentation is a post infectious origin. The aim of this study was to determine the clinical features, etiology, and radiologic findings of post infectious BO, which was diagnosed by high resolution computed tomography (HRCT). The results were then compared to those of the control group.
METHODS
We diagnosed 52 children with BO by a review of all performed HRCT findings at Severance Children's Hospital between January 2007 and March 2011. A retrospective study was conducted to define the clinical features, etiology, symptoms, and radiologic findings of post infectious BO. Sixty-five children who were diagnosed with lower respiratory infection confirmed by HRCT were defined as the control group for comparison with post infectious BO patients.
RESULTS
The mean age of the patients at the time of diagnosis with BO was 41.3+/-5.9 months, and that of the control group was 57.1+/-5.1 months. The initial insult age of BO patients was 14.6+/-2.8 months, and that of the control group was 50.9+/-5.0 months. The frequency of previous admissions due to lower respiratory infection was relatively higher in BO patients than the control group.
CONCLUSION
The results suggest that the development of post infectious BO should be early suspected and HRCT should be performed in children with a recurrent admission history of lower respiratory infection, especially in those younger than 2 years of age. Furthermore, continued management of prevent additional infection should be conducted.

Keyword

Bronchiolitis obliterans; High resolution computed tomography; Child

MeSH Terms

Bronchiolitis
Bronchiolitis Obliterans
Child
Humans
Pulmonary Disease, Chronic Obstructive
Retrospective Studies

Figure

  • Fig. 1 Clinical features of the patients with bronchiolitis obliterans at diagnosis.

  • Fig. 2 High-resolution computerized tomography findings of the patient with bronchiolits obliterans.


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