Pediatr Allergy Respir Dis.  2012 Sep;22(3):265-272.

Clinical Manifestations of Respiratory Viruses in Hospitalized Children with Acute Viral Lower Respiratory Tract Infections from 2010 to 2011 in Busan and Gyeongsangnam-do, Korea

• Kim HY
• Kim KM
• Kim SH
• Son SK
• Park HJ

Abstract

PURPOSE
This study was performed to investigate the epidemiologic and clinical features of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Busan and Gyeongsangnam-do, Korea.
METHODS
From May 2010 to April 2011, we tested nasopharyngeal aspiration specimens in 1,520 hospitalized children with ALRTI with multiplex real time-polymerase chain reaction (RT-PCR) to identify 7 kinds of common pathogens (adenovirus [ADV], influenza virus type A [influ A], influenza virus type B [influ B], human metapneumovirus [hMPV], parainfluenza virus [PIV], human rhinovirus [hRV], respiratory syncytial virus [RSV]). We analyzed positive rates and clinical features by retrospective review of the chart.
RESULTS
Virus agents were isolated from 72.5% of cases. The identified pathogens were RSV, 35.5%; hRV, 25.6%; PIV, 13.8%; ADV, 12.8%; hMPV, 7.1%; influ A, 5.0%; and influ B, 0.3%. The major period of viral ALRTI was the first year of life. Clinical diagnoses of viral ALRTI were pneumonia, 52.3%; bronchiolitis, 21.2%; tracheobronchitis, 1.0%; croup, 10.8%; and asthma, 8.8%. The most frequent case of pneumonia and bronchiolitis was RSV. Croup was frequently caused by PIV. The number of hMPV infections peaked between April and June and were primarily caused due to pneumonia.
CONCLUSION
Although this study was confined to one year, this study described the features of ALRTI associated with 7 respiratory viruses in children in Busan and Gyeongsangnam-do, Korea. Additional investigations are required to define the role of respiratory viruses in children with ALRTI in this area.

Keyword

Respiratory tract infection; Epidemiology; Respiratory virus; RT-PCR; Children

MeSH Terms

Asthma
Bronchiolitis
Child
Child, Hospitalized
Croup
Humans
Korea
Metapneumovirus
Orthomyxoviridae
Paramyxoviridae Infections
Pneumonia
Respiratory Syncytial Viruses
Respiratory System
Respiratory Tract Infections
Retrospective Studies
Rhinovirus
Viruses

Figure

• 

  Fig. 1 Age distribution in children with acute viral lower respiratory tract infections caused by specific viruses from 2010 to 2011. ADV, adeno-virus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumo-virus; PIV, parainfluenza virus; hRV, human rhino-virus; RSV, respiratory syncytial virus.

• 

  Fig. 2 Monthly incidence of acute lower respiratory tract infections caused by specific viral agents from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

• 

  Fig. 3 Distribution of viral agents according to clinical patterns in children with acute lower respiratory tract infections from 2010 to 2011. ADV, adenovirus; Influ A, influenza virus type A; Influ B, influenza virus type B; hMPV, human metapneumovirus; PIV, parainfluenza virus; hRV, human rhinovirus; RSV, respiratory syncytial virus.

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