Pediatr Allergy Respir Dis.  2012 Mar;22(1):45-53.

The Level of Serum Immunoglobulin E Measured at General Hospitals in Six Regions of Korea in Children with Allergic Diseases

Affiliations
  • 1Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea. jaewonoh@hanyang.ac.kr
  • 2Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea.
  • 3Department of Pediatrics, Gwangju Veterans Hospital, Gwangju, Korea.
  • 4Department of Pediatrics, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.
  • 5Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 6Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
  • 7Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
  • 8Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 9Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 10Department of Pediatrics, Bucheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Bucheon, Korea.
  • 11Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 12Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 13Department of Internal Medicine, Seoul National University University, Seoul National University College of Medicine, Seoul, Korea.
  • 14Allergy TF, Department of Immunology and Pathology, Korea National Institute of Health, Cheongwon, Korea.

Abstract

PURPOSE
We investigated the change in serum total immunoglobulin E (IgE) and allergen-specific IgE according to allergic diseases and age.
METHODS
Allergic markers of children under 18 years of age with allergic diseases for the last 5 years were collected from 12 hospitals nationwide. The total data was 9,710. Data about levels of serum total IgE and allergen-specific IgE to 15 common allergens were collected.
RESULTS
In children with asthma, serum total IgE was higher in older age than in younger age until age 7 to 12 years, at which time the level was highest (paper radioimmunosorbent test, 526.7 IU/mL; UniCAP, 339.9 IU/mL). The level was lower in older age than that during younger age. This change was similar to that in children with allergic rhinitis and atopic dermatitis. The level was highest at ages 7 to 12 years in children with allergic rhinitis, and at age 10 to 12 years in children with atopic dermatitis. In children with both asthma and allergic rhinitis, as well as in children with all three diseases, the change in serum total IgE was similar to that of children with an isolated disease. The highest level in children with all three diseases was higher than that in children with an isolated disease. The analysis of allergen-specific IgE positivity showed that food allergens were dominant before the age of 2 years, and that aeroallergens such as house dust mites were dominant.
CONCLUSION
Serum total IgE in Korean children with allergic diseases was higher in older age than in younger age until the ages of 7 to 12 years, and then the change in total IgE by age was the opposite.

Keyword

Asthma; Allergic rhinitis; Atopic dermatitis; Immunoglobulin E; Allergen-specific IgE
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