Pediatr Allergy Respir Dis.
2010 Mar;20(1):30-40.
Relationship between Allergic Rhinitis and Asthma in High School Students in Korea
- Affiliations
-
- 1Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, College of Medicine, Ulsan University, Korea. sjhong@amc.seoul.kr
- 2Department of Pediatrics, Gangneung Asan Hospital, Asan Medical Center, College of Medicine, Ulsan University, Gangneung, Korea.
- 3Department of Pediatrics, Ulsan Asan Hospital, Asan Medical Center, College of Medicine, Ulsan University, Ulsan, Korea.
- 4Department of Pediatrics, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- 5Department of Family medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
- 6Department of Pediatrics, Pyoungchon Secred Heart Hospital, College of Medicine, Hallym University, Korea.
Abstract
- PURPOSE
The aim of this study was to determine whether allergic rhinitis (AR) without asthma is associated with bronchial hyperresponsiveness (BHR) and symptoms of asthma in Korean adolescents.
METHODS
A questionnaire survey was conducted on 724 high school students (males 556; females, 168) from Seoul City. We also performed the lung function test, methacholine challenge test, skin prick test, and allergy-related blood biomarkers. This cross-sectional study was conducted in the subjects excluding current asthmatic patients.
RESULTS
AR (+), BHR (+) patients tended to show a high prevalence of wheeze ever, a high diagnosis rate of asthma ever, low forced expiratory volume in one second (FEV(1)), low forced expiratory flow at the 25% and 75% of pulmonary volume (FEF(25-75%)) high total IgE and frequent sensitizaion to house dust mites compared with AR (-), BHR (-) patients. In atopy AR (+) group, wheeze ever and treatment of asthma during the last 12 months were significantly higher than atopy (-), AR (-) patients or atopy (+), AR (-) patients (P<0.05). In atopy (+), AR (+) patients, BHR and peripheral eosinophil percent were significantly higher than in other patients (P<0.05) and PC(20) was also significantly lower than in other patients (P<0.05).
CONCLUSION
BHR in current AR was associated with FEV(1), FEF(25-75%), total IgE, and sensitization to house dust mites. Current AR was associated with symptoms of asthma, peripheral eosinophilia and BHR, regardless of atopy. This study showed a significant association between allergic rhinitis and asthma or BHR among Korean adolescents. This cross-sectional study supports the concept of 'one airway, one disease' between the AR and asthma.
MeSH Terms
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Adolescent
Asthma
Biomarkers
Cross-Sectional Studies
Eosinophilia
Eosinophils
Female
Forced Expiratory Volume
Humans
Immunoglobulin E
Korea
Methacholine Chloride
Prevalence
Pyroglyphidae
Surveys and Questionnaires
Respiratory Function Tests
Rhinitis
Rhinitis, Allergic, Perennial
Skin Tests
Immunoglobulin E
Methacholine Chloride
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