Pediatr Allergy Respir Dis.  2001 Jun;11(2):138-145.

Factors Associated with Retreatment of Intravenous Gamma-Glubulin in Kawasaki Disease

• Lee CH
• Kim YJ
• Park WS
• Lee MI
• Park JE

Abstract

PURPOSE
In most patients of Kawasaki disease(KD), fever subsides within 48 hours after infusion of intravenous immunoglobulin(IVIG), but in some cases, retreatment of IVIG is needed because of prolonged fever. This study was performed to findout the factors associated with the retreatment of IVIG in KD.
METHODS
Patients with KD, treated with IVIG were classified into two groups : single IVIG treatment group(defeverescence within 48 hours after starting IVIG : group B) and IVIG retreatment group(retreatment with IVIG for fever over 48 hours despite the 1st infusion of IVIG; group A). We compared the clinical symptoms, laboratory findings, clinical signs and echocardiogram findings between group A and B.
RESULTS
The mean CRP level of group A was higher than that of group B(P= 0.001), and the mean cholesterol level of group A was lower than that of group B(P=0.002). In CRP level is above 10 mg/dL, odds ratio for retreatment of IVIG is higher than that of level below 10 mg/dL. As cholesterol level decreased, the odds ratio for retreatment with IVIG increased.
CONCLUSION
When readministration of IVIG in KD patients for prolonged fever over 48 hours, the consideration of the initial levels of relatively low serum cholesterol and high CRP is recommended.

Keyword

Kawasaki disease; Immunoglobulin; CRP; Cholesterol

MeSH Terms

Cholesterol
Fever
Humans
Immunoglobulins
Immunoglobulins, Intravenous
Mucocutaneous Lymph Node Syndrome*
Odds Ratio
Retreatment*
Cholesterol
Immunoglobulins
Immunoglobulins, Intravenous