Osteoporosis.
2013 Aug;11(2):74-80.
A Retrospective Study of Bone Mineral Density in Patients with Endometrial Cancer without Bone Metastases
- Affiliations
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- 1Department of Obstetrics & Gynecology, College of Medicine, Kosin University, Busan, Korea. ttochil@hanmail.net
- 2Department of Obstetrics and Gynecology, Samsung Changwon Hospital, School of Medicine, Sungkyungkwan University, Changwon, Korea.
- 3Department of Obstetrics and Gynecology, Inha University College of Medicine, Incheon, Korea.
- 4Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea. ttochil@hanmail.net
Abstract
OBJECTIVES
This retrospective study evaluated bone mineral density (BMD) in postmenopausal endometrial cancer patients without bone metastases.
MATERIALS AND METHODS
We retrospectively analyzed the BMD of spinal bone and the femur in 26 endometrial cancer patients and 32 control women. All of the patients and control women had reached their menopause. The control group was treated with benign uterine myoma whose age and body mass index are consistent with the case group. All BMD was measured by dual-energy X-ray absorptiometry.
RESULTS
Among the serum calcium concentrations and bone markers, alkaline phosphatase level was higher in endometrial cancer group than in controls. BMD of 4th lumbar vertebra was significantly lower in endometrial cancer patients (T-score: -0.63+/-0.77) than in controls (T-score: 0.88+/-1.83). Serum calcium concentration was higher in stage I patients (9.63+/-0.31 mg/dL) than that in stage II-III patients (9.26+/-0.31 mg/dL). BMD of 1st vertebra was lower in stage I patients (T-score: -1.80+/-0.97) than that in stage II-III patients (T-score: -0.60+/-0.95).
CONCLUSIONS
We observed the increase of bone turnover along with the decrease of BMD in endometrial cancer which is estrogen dependent malignancy. Bone turnover increase and BMD decrease was even more distinct in early stage of endometrial cancer than later stages. A prospective randomized trial in large scale is warranted to elucidate the relation between the factors affecting bone density in endometrial cancer.
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