Osteoporosis.
2013 Aug;11(2):66-73.
Effect on Bone Mineral Density in Postmenopausal Invasive Cervical Cancer Patients with Radical Operation and CCRT
- Affiliations
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- 1Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea.
- 2Department of Obstetrics and Gynecology, Samsung Changwon Hospital, School of Medicine, Sungkyungkwan University, Changwon, Korea.
- 3Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
- 4Department of Obstetrics & Gynecology, College of Medicine, Kosin University, Busan, Korea. hykyale@yahoo.com
- 5Department of Obstetrics and Gynecology, College of Medicine, Inha University, Seoul, Korea.
Abstract
OBJECTIVES
This study evaluated the effect on bone mineral density (BMD) in postmenopausal invasive cervical cancer patients treated with radical operation and concurrent chemoradiotherapy (CCRT).
METHODS
We analyzed the BMD of spinal bone and the femur in 48 invasive cervical cancer patients treated with CCRT after radical operation. All BMD was measured by dual-energy X-ray absorptiometry. For comparison with control women, 96 patients without gynecological disease whose age and body mass index are consistent with the case group were selected. The measurement interval was 1 year. All of the patients and control women had reached their menopause.
RESULTS
Age, height, body weight and body mass index were not significantly different between the two groups. The serum levels of calcium and phosphate were not significantly different between the patients with cervical cancer and control women before and after treatment. On the other hands, the concentrations of total alkaline phosphatase and osteocalcin of patients with invasive cervical cancer were significantly lower (P<0.05) than those of control women after treatment. BMD showed inconsistent outcomes, but there is a trend of decrease after operation and CCRT in invasive cervical cancer.
CONCLUSIONS
Our study suggests that invasive cervical cancer patients treated with radical operation and CCRT have a lower BMD, resulting in an increased risk of osteoporosis.
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