Osteoporosis.  2011 Apr;9(1):126-131.

To Investigate the Incidence of Non-responder to Hormone Therapy and the Bone Response in Postmenopausal Women

Affiliations
  • 1Department of Obstetrocs & Gynecology, College of Medicine, Kosin University, Busan, Korea. marianna1113@naver.com
  • 2Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea.
  • 3Department of Obstetrics and Gynecology, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, School of Medicine, Konkuk University, Seoul, Korea.
  • 5Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje university, Busan, Korea.
  • 6Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.
  • 7Department of Obstetrics and Gynecology, School of Medicine, Gyeongsang National University, Jinju, Korea.

Abstract


OBJECTIVES
To investigate the incidence of non-responder to hormone therapy (HT) and to evaluate the bone response to HT according to basal bone mineral density(BMD) in postmenopausal women.
METHODS
A total of 167 postmenopausal women received either continuous combined estrogenprogestogen replacement (n=102) or estrogen replacement (n=65) for 1 years. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (DXA) before and 1 year after HT.
RESULTS
The incidence of non-responder (women with >3% bone loss per year) to HT was 8.3% in the lumbar spine, and 22.1% in femoral neck. non-responder group had a higher basal BMD at the lumbar spine than responder group, and showed bone loss rate of 7.7% per year. After 1 year of HT, postmenopausal women with osteoporosis showed a higher rate of increase in BMD at the lumbar spine and femoral neck than women with normal BMD or osteopenia.
CONCLUSIONS
The non-responders to HT have a higher basal lumbar BMD, compared with responders. The higher basal BMD at the lumbar spine is, the less bone conservation effect of HT is.

Keyword

Bone conservation; Hormone therapy
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