Osteoporosis.  2011 Apr;9(1):46-50.

Decreased Bone Mineral density of Spine in Patients with Invasive Cervical Cancer

Affiliations
  • 1Department of Obstetrics and Gynecology, School of Medicine, Sanggye Paik Hospital, Inje University, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University, Busan, Korea.
  • 4Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.
  • 5Department of Obstetrics and Gynecology, School of Medicine, Konkuk University, Seoul, Korea.
  • 6Department of Obstetrics and Gynecology, School of Medicine, Gyeongsang National University, Jinju, Korea.
  • 7Department of Obstetrics and Gynecology, College of Medicine, Wonkwang University, Gunpo, Korea.
  • 8Department of Family Medicine, Kosin University, Busan, Korea.
  • 9Department of Obstetrics and Gynecology, Kosin University, Busan, Korea. hykyale@yahoo.com

Abstract


OBJECTIVES
To investigate the spinal bone mineral density (BMD) in patients with invasive cervical cancer without bone metastases.
METHODS
We measured spinal bone mineral densities by dual-photon absorptiometry in 119 patients with invasive uterine cervical cancer and compared them with measurements from 135 control women.
RESULTS
When adjusted for age, mean bone mineral density in patients with uterine cervical cancer was 13.9% lower (P=0.0003) and age-matched percentiles were 9.2% lower (P=0.0003) than in control women. The deficits in bone mineral density and age-matched percentiles were confined to the uterine cervical cancer patients in their fifties.
CONCLUSIONS
Our study results suggest that patients with invasive cervical cancer have a lower spinal BMD, resulting in an increased risk of osteoporosis.

Keyword

Bone mineral density; Cervical cancer; Osteoporosis
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