Nutr Res Pract.  2015 Dec;9(6):673-676. 10.4162/nrp.2015.9.6.673.

Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study

Affiliations
  • 1Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
  • 2Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea. mjhan@khu.ac.kr
  • 3R & D center, CTCBIO Inc., Gyeonggi 445-913, Korea.

Abstract

BACKGROUND/OBJECTIVES
Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans.
MATERIALS/METHODS
Capsules (300 mg) containing Lactobacillus brevis G101 (1x1010 CFU/individual) or maltodextrin (placebo) was orally administered in 30 respondents with self-recognized monosodium glutamate (MSG) symptom complex for 5 days and the rice with black soybean sauce containing 6 g MSG (RBSM) was ingested 30 min after the final administration. Thereafter, the MSG symptom complex (rated on a 5-point scale: 1, none; 5, strong) was investigated in a double blind placebo controlled study. The intensity of the MSG symptom complex was significantly reduced in respondents of the G101 intake group (2.87 +/- 0.73) compared to that in those treated with the placebo (3.63 +/- 1.03) (P = 0.0016). Respondents in the placebo group exhibited more of the various major conditions of the MSG symptom complex than in the G101 intake group. Although there was no significant difference in the appearance time of the MSG symptom complex between subjects orally administered G101 and those administered the placebo, its disappearance in < 3 h was observed in 69.9% of subjects in the G101 treatment group and in 38.0% of subjects in the placebo group (P = 0.0841).
CONCLUSIONS
Oral administration of Lactobacillus brevis G101 may be able to reduce the intensity of the MSG symptom complex.

Keyword

Monosodium glutamate; side effect; Lactobacillus brevis G10; blind study

MeSH Terms

Absorption
Administration, Oral
Animals
Capsules
Surveys and Questionnaires
Humans
Intestines
Lactobacillus brevis*
Lactobacillus*
Mice
Sodium Glutamate*
Soybeans
Capsules
Sodium Glutamate

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