Nutr Res Pract.  2011 Oct;5(5):435-442.

A mixture of Salacia oblonga extract and IP-PA1 reduces fasting plasma glucose (FPG) and low-density lipoprotein (LDL) cholesterol levels

• Nakata K
• Taniguchi
• Yoshioka N
• Yoshida A
• Inagawa H
• Nakamoto T
• Yoshimura
• Miyake SI
• Kohchi C
• Kuroki M
• Soma GI

Abstract

At present, lifestyle-related diseases are one of the most critical health issues worldwide. It has been reported that lipopolysaccharide derived from a Gram-negative bacteria (IP-PA1) symbiotic with wheat exhibited several advantageous biological effects, such as the reduction of plasma glucose levels in NOD mice and low-density lipoprotein (LDL) levels in WHHL rabbits. In this study, the beneficial effects on plasma glucose and lipids of a tea (SI tea) consisting of IP-PA1 and Salacia (which contains an inhibitor of alpha-glucosidase) were investigated in the KK-Ay/TaJcl type 2 diabetic model mice and in human subjects with premetabolic syndrome in a double-blind, randomized study. SI tea significantly decreased plasma glucose levels in KK-Ay/TaJcl mice. A clinical trial of SI tea was performed with 41 subjects between the ages of 40 and 69, who belonged either to a high plasma glucose group (HG: FPG 100-125 mg/dl) or to a hyperlipidemia group (HL: TG > or = 150 mg/dl, or LDL > or = 120 mg/dl, or HDL < 40 mg/dl). These subjects ingested either Salacia without IP-PA1 (the control) or SI tea. Blood samples were collected at 0, 30, and 60 days after initiating SI tea treatment, and were measured for FPG, HbA1c, TG, LDL, and HDL. These results showed that SI tea reduced FPG and HbA1c more rapidly than the control in the HL group, and also significantly improved LDL and HDL levels in the HG group. Thus, SI tea may be helpful in preventing lifestyle-related diseases.

Keyword

LPS; Salacia; type 2 diabetes; hyperlipemia; lifestyle-related diseases

MeSH Terms

Animals
Cholesterol
Fasting
Glucose
Gram-Negative Bacteria
Humans
Hyperlipidemias
Lipoproteins
Mice
Mice, Inbred NOD
Plasma
Rabbits
Salacia
Tea
Triticum
Cholesterol
Glucose
Lipoproteins
Tea

Figure

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  Fig. 1 Change in body weight by SI tea in KK-Ay/TaJcl mice. The values are mean ± SD.

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  Fig. 2 Change in plasma glucose levels by SI tea in KK-Ay/TaJcl mice. The values are means ± SD. a) Differences between the DW group and the Salacia tea control group, or the DW group and the SI tea group were analyzed using the Tukey-Kramer multiple comparison post tests at P < 0.01. b) Differences between the Salacia tea control group and the SI tea group were analyzed using the Tukey-Kramer multiple comparison post-tests at SI, P < 0.01.

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  Fig. 3 Change in glucose metabolism markers. Effect of SI tea on FPG and HbA1c in humans during a 60-day period. ▪: HG control; ♦: HG SI tea; □: HL control; ⋄: HL SI tea. Values are mean ± SD. Differences in 30 day- or 60 day-values adjusted for variation in 0 day-values using the Tukey-Kramer multiple comparison post-tests. *P < 0.05, **P < 0.01.

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  Fig. 4 Change in lipid metabolism markers. Effect of SI tea on TG, LDL, and HDL in humans during a 60-day period. ▪: HG control; ♦: HG SI tea; □: HL control; ⋄: HL SI tea. Values are means ± SD. Differences in 30 day- or 60 day-values adjusted for variation in 0 day-values using the Tukey-Kramer multiple comparison post-tests. *P < 0.05, **P < 0.01.

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