Nutr Res Pract.  2009 Mar;3(1):15-22.

Effect of Chlorella intake on Cadmium metabolism in rats

Affiliations
  • 1Department of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750, Korea. mkk@ewha.ac.kr

Abstract

This study was performed to investigate the effect of chlorella on cadmium (Cd) toxicity in Cd- administered rats. Sixty male Sprague-Dawley rats (14 week-old) were blocked into 6 groups. Cadmium chloride was given at levels of 0 or 325 mg (Cd: 0, 160 ppm), and chlorella powder at levels of 0, 3 and 5%. Cadmium was accumulated in blood and tissues (liver, kidney and small intestine) in the Cd-exposed groups, while the accumulation of Cd was decreased in the Cd-exposed chlorella groups. Fecal and urinary Cd excretions were remarkably increased in Cd-exposed chlorella groups. Thus, cadmium retention ratio and absorption rate were decreased in the Cd exposed chlorella groups. Urinary and serum creatinine, and creatinine clearance were not changed in experimental animals. In addition, metallothionein (MT) synthesis in tissues was increased by Cd administration. The Cd-exposed chlorella groups indicated lower MT concentration compared to the Cd-exposed groups. Moreover, glomerular filtration rate (GFR) was not changed by dietary chlorella and Cd administration. According to the results above, this study could suggest that Cd toxicity can be alleviated by increasing Cd excretion through feces. Therefore, when exposed to Cd, chlorella is an appropriate source which counteracts heavy metal poisoning, to decrease the damage of tissues by decreasing cadmium absorption.

Keyword

Chlorella; cadmium; excretion; heavy metal; metallothionein (MT)

MeSH Terms

Absorption
Animals
Cadmium
Cadmium Chloride
Chlorella
Creatinine
Feces
Glomerular Filtration Rate
Humans
Kidney
Male
Metallothionein
Metals, Heavy
Poisoning
Rats
Rats, Sprague-Dawley
Retention (Psychology)
Cadmium
Cadmium Chloride
Creatinine
Metallothionein
Metals, Heavy
Poisoning

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