Nutr Res Pract.  2007 Dec;1(4):363-370.

Adiponectin gene SNP 276G --> T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients

• Yu SY
• Ryu HK
• Park HJ
• Choi YJ
• Huh KB
• Kim WY

Abstract

Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G-->T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G-->T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype. However, in T/T genotype, there was no significant association between macronutrient intakes and anthropometric and hematological values. In conclusion, CVD risk would be high in type 2 DM patients with T/T genotype, and the association of macronutrient intakes with anthropometric and hematologic factors was different among the three adiponectin genotypes. These results may imply the need for different dietary management regime according to adiponectin genotype to lower CVD complications in Korean type 2 DM patients.

Keyword

Adiponectin SNP 276G-->T; adiponectin; insulin resistance; type 2 diabetes; cardiovascular disease risk factors

MeSH Terms

Adiponectin*
Body Weight
C-Reactive Protein
Cardiovascular Diseases*
Diabetes Mellitus, Type 2
Genotype
Humans
Insulin Resistance
Male
Polymorphism, Single Nucleotide
Prevalence
Surveys and Questionnaires
Risk Factors
Seoul
Waist Circumference
Waist-Hip Ratio
Adiponectin
C-Reactive Protein

Figure

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  Fig. 1 PCR-based Bsm-RFLP analysis of the intron-2 polymorphism of the adiponectin gene

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  Fig. 2 Serum adiponectin concentration according to adiponectin genotype in the each subgroups of median of BMI, fasting blood sugar, triglyceride, and TNF-α

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