Nucl Med Mol Imaging.  2016 Mar;50(1):24-30. 10.1007/s13139-015-0363-z.

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Affiliations
  • 1Department of Nuclear Medicine, Korea University Guro Hospital, Seoul, South Korea.
  • 2Department of Nuclear Medicine, Korea University Anam Hospital, #73, Inchon-ro, Seongbuk-gu, Seoul 136-705, South Korea. seiong@korea.ac.kr
  • 3Department of Nuclear Medicine, G Sam Hospital, Gunpo, South Korea.
  • 4Department of Neuroscience, College of Medicine,Korea University, Seoul, South Korea.

Abstract

PURPOSE
The aimof this study was to evaluate the relationship between semiquantitative parameters on 18F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC).
METHODS
Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18F-FDG PET/ CT images. The protein expression of Ki-67 was examined by immunohistochemical staining.
RESULTS
Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p= 0.526 and 0.729, respectively).
CONCLUSION
In conclusion, the volume-based parameters of 18F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

Keyword

Small-cell lung carcinoma; 18F-FDGPET/CT; Metabolic tumor volume; Ki-67

MeSH Terms

Fluorodeoxyglucose F18*
Glycolysis
Humans
Lung Neoplasms
Positron-Emission Tomography and Computed Tomography*
Small Cell Lung Carcinoma*
Tumor Burden
Fluorodeoxyglucose F18
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