Nucl Med Mol Imaging.  2015 Jun;49(2):108-114. 10.1007/s13139-014-0304-2.

Correlation Analysis and Prognostic Impact of 18F-FDG PET and Excision Repair Cross-Complementation Group 1 (ERCC-1) Expression in Non-Small Cell Lung Cancer

• Jeong YH
• Lee CK
• Jo K
• Hwang SH
• Cha J
• Lee JW
• Yun M
• Cho A

• KMID: 2313256
• DOI: http://doi.org/10.1007/s13139-014-0304-2

Abstract

PURPOSE
The aim of this study was to determine the relationship between [18]-2-fluoro-2-deoxy-D-glucose (FDG) uptake and excision repair cross-complementation group 1 (ERCC-1) expression and to evaluate the prognostic effect of these two factors in resectable non-small cell lung cancer (NSCLC) patients.
METHODS
We retrospectively reviewed 212 patients with resectable NSCLC who underwent FDG positron emission tomography/computed tomography (PET/CT) scan for cancer staging and ERCC-1 expression analysis between January 2008 to December 2011. All patients were then followed-up for survival analysis. Semiquantitative evaluation of ERCC-1 was performed with the H-scoring system and was correlated with maximum standardized uptake value (SUVmax) of NSCLC. Univariate andmultivariate analyseswere performed to evaluate for FDG uptake and ERCC-1 expression predicting overall survival.
RESULTS
In 212 patients (139 male, median age 68+/-9.11), 112 patients had ERCC-positive tumors and 100 patients had ERCC-negative tumors. There was no significant difference in SUVmax between ERCC-1-positive tumors (8.02+/-5.40) and ERCC-1-negative tumors (7.57+/-6.56, p=0.584). All patients were followed-up for a median of 40.5 months (95 % confidence interval [CI], 38.5-42.2 months). Univariate analysis and multivariate analysis for all patients showed that both ERCC-1 expression (hazard ratio [HR], 2.78; 95 % CI, 1.20-6.47) and FDG uptake (HR, 4.50; 95 % CI, 2.07-9.77) independently predicted overall survival.
CONCLUSIONS
We have found no statistical correlation between FDG uptake and ERCC-1 expression in NSCLC. However, both higher FDG uptake and positive ERCC-1 expression are independent predictive markers of prognosis, suggesting that both should be obtained during patient workup.

Keyword

FDG; PET/CT; ERCC; NSCLC; Prognosis

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
DNA Repair*
Electrons
Fluorodeoxyglucose F18*
Humans
Male
Multivariate Analysis
Neoplasm Staging
Positron-Emission Tomography and Computed Tomography
Prognosis
Retrospective Studies
Fluorodeoxyglucose F18