Nucl Med Mol Imaging.
2014 Jun;48(2):91-97.
Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma
- Affiliations
-
- 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. jkchung@plaza.snu.ac.kr
- 2Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Korea.
- 3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- 4Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
- 5Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 7Department of Nuclear Medicine, Seoul National University Hospital, 28 Yongon-dongChongno-gu Seoul 110-744, Korea.
Abstract
- PURPOSE
The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades.
MATERIALS AND METHODS
Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n=13) and relatively less differentiated group (n=11).
RESULTS
Glut-1 gene expression was significantly higher in the less differentiated group (0.66+/-0.04) than in the well-differentiated group (0.59+/-0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67+/-0.20, PD: 0.65+/-0.21, TG: 0.74+/-0.16) than in the less differentiated group (NIS: 0.36+/-0.05, PD: 0.49+/-0.08, TG: 0.60+/-0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD.
CONCLUSION
The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PETor radioiodine whole-body scan and I-131-based therapy.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Concurrent Medullay and Papillary Carcinoma of the Thyroid
- Medullary and Papillary Thyroid Carcinoma as a Collision Tumor: Report of Five Cases
- A Case of Ectopic Thyroid Papillary Carcinoma with Incidental Papillary Thyroid Microcarcinoma
- Concurrent Papillary and Medullary Carcinoma of the Thyroid Gland
- Expression of p53 and MDM2 Proteins in Thyroid Carcinomas
