Nat Prod Sci.  2016 Mar;22(1):1-12. 10.20307/nps.2016.22.1.1.

Analysis of Flavonoid Composition of Korean Herbs in the Family of Compositae and their Utilization for Health

• Nugroho A
• Choi JS
• Park HJ

• KMID: 2312914
• DOI: http://doi.org/10.20307/nps.2016.22.1.1

Abstract

Compositional differences in flavonoids are varied in the big family of Compositae. By summarizing our previous analytical studies and other scientific evidences, new strategy will be possible to further analyze flavonoids and utilize them for human health. The HPLC analytical method has been established in terms of linearity, sensitivity, accuracy, and precision. Herbs of the family of Compositae have considerable amounts of peroxynitrite (ONOO-)-scavenging effects and their phenolic substances. These effects may contribute to the prevention of disease associated with excess production of ONOO-, depending on the high content of flavonoid substances.

Keyword

Compositae; Flavonoids; Phenolic substance; HPLC analysis; Peroxynitrite

MeSH Terms

Asteraceae*
Chromatography, High Pressure Liquid
Flavonoids
Humans
Peroxynitrous Acid
Phenol
Flavonoids
Peroxynitrous Acid
Phenol

Figure

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  Fig. 1. Characteristics of Compositae. The head with ray florets arranged around the perimeter, disc florets in the center, and an involucre with bracts (phyllaries) surrounding the outermost florets. B. The pollen is released via the style pushing out through the anthers, which are fused at the margins; sometimes the style branches are recurved and come in contact with the style shaft. C. Some of the achene (cypsela) and pappus types found in Compositae (Funk et al., 2009).

• 

  Fig. 2. Traditional use of Hemitepta lyrata as one of Compositae herbs.

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  Fig. 3. Chemical structures of several flavonols and flavones.

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  Fig. 4. Structure of luteolin, acacetin, Lut-7-Glc, Lut-7-GlcU and acacetin identified from Y. japonica and their presumed pathway. A dotted arrow represents a less favored pathway.

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  Fig. 5. HPLC chromatograms of MeOH extracts of the four Compositae herbs (Compound names are abbreviated).

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  Fig. 6. Composition of flavonoids and caffeoylquinic acids in the five Compositae herbs.

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  Fig. 7. Peroxynitrite-scavenging activities (IC50 s) of the flavonoids and caffeoylquinic acids identified in the five Compositae herbs.

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