Nat Prod Sci.  2015 Sep;21(3):150-154. 10.0000/nps.2015.21.3.150.

Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce

• Dat LD
• Thao NP
• Tai BH
• Luyen BT
• Yang SY
• Kim S
• Koo JE
• Koh YS
• Cuong NT
• Nam NH
• Thanh NV
• Kiem PV
• Minh CV
• Kim YH

• KMID: 2312889
• DOI: http://doi.org/10.0000/nps.2015.21.3.150

Abstract

Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-alpha) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 microM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-alpha (IC50 values of 1.7 +/- 0.1 and 5.5 +/- 0.2 microM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 +/- 0.4 and 3.3 +/- 0.1 microM, respectively).

Keyword

Kandelia candel; Rhizophoraceae; IL-12 p40; IL-6; TNF-alpha; Anti-inflammation

MeSH Terms

Cytokines
Dendritic Cells
Glycosides*
Interleukin-12
Interleukin-6
Rhizophoraceae*
Triterpenes*
Tumor Necrosis Factor-alpha
Cytokines
Glycosides
Interleukin-12
Interleukin-6
Triterpenes
Tumor Necrosis Factor-alpha