Mycobiology.
2015 Mar;43(1):43-48. 10.5941/MYCO.2015.43.1.43.
Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity
- Affiliations
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- 1Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, Iksan 570-752, Korea. bsyun@jbnu.ac.kr
- 2Korea National College of Agriculture and Fisheries, Hwaseong 445-760, Korea.
- KMID: 2312792
- DOI: http://doi.org/10.5941/MYCO.2015.43.1.43
Abstract
- The medicinal fungus Phellinus linteus, in the family Hymenochaetaceae, has been used as a traditional medicine for the treatment of various diseases. In this study, the chemical constituents of the culture broth of P. linteus were investigated. P. linteus was cultured in potato dextrose broth medium, and the culture broth was extracted with ethyl acetate. The ethyl acetate-soluble portion was concentrated and subjected to ODS column chromatography, followed by Sephadex LH-20 column chromatography. Six compounds (1~6) were purified by preparative reversed-phase high-performance liquid chromatography. Spectroscopic methods identified their structures as caffeic acid (1), inotilone (2), 4-(3,4-dihydroxyphenyl)-3-buten-2-one (3), phellilane H (4), (2E,4E)-(+)-4'-hydroxy-gamma-ionylideneacetic acid (5), and (2E,4E)-gamma-ionylideneacetic acid (6). Compounds 1, 2, and 3 exhibited potent dose-dependent antioxidant activity.
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