Mycobiology.
2007 Mar;35(1):25-29.
Biological Screening of a Novel Nickel (II) Tyrosine Complex
- Affiliations
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- 1Genetic Engineering Department, Chittagong University, Chittagong-4331, Bangladesh.
- 2Biochemistry and Molecular Biology Department, Chittagong University, Chittagong-4331, Bangladesh.
- 3Biochemistry and Molecular Biology Department, Rajshahi University, Rajshahi-6205, Bangladesh.
- 4Department of Applied Chemistry & Chemical Technology, University of Rajshahi, Rajshahi-6205, Bangladesh.
- 5Department of Botany, Rajshahi University, Rajshahi-6205, Bangladesh.
- 6Department of Biology, Dongguk University, Seoul 100-715, Korea. mwlee@dgu.ac.kr
Abstract
- A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria (Bacillus subtilis, Streptococcus beta-haemolytica, Escherichia coli, Shigella dysenterae) and fungi (Aspergillus fumigatus, Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium sp.) strains. were used for antifungal activity. The antimicrobial activity was evaluated using the Agar Disc method. Moreover, the minimum inhibitory concentration of the complexes was determined against the same pathogenic bacteria and the values were found between 4~64 microg ml(-1). Brine shrimp bioassay was carried out for cytotoxicity measurements of the complexes. The LC50 values were calculated after probit transformation of the resulting mortality data and found to be 6 microg ml(-1).
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