Mycobiology.  2003 Jun;31(2):95-98.

In Vitro Antifungal Activities of Amphotericin B, Fluconazole, Itraconazole, Terbinafine, Caspofungin, Voriconazole, and Posaconazole against 30 Clinical Isolates of Cryptococcus neoformans var. neoformancs

Affiliations
  • 1Seoul Government Research Institute of Public Health & Environment, Korea. pp99pp@dreamwiz.com
  • 2Fungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center at San Antonio, USA.

Abstract

Aantifungal agents were tested against 30 clinical isolates of Cryptococcus neoformans var. neoformans using the NCCLS method (M27-A2). Posaconazole, itraconazole and amphotericin B had lower MIC than the remaining four antifungal agents. The MIC result for posaconazole was over 220-fold lower active than fluconazole. Fluconazole MICs for most isolates fell within the dose-dependant range. The overall MIC ranges and MIC50s were amphotericin B (0.03-0.25; 0.25), fluconazole (0.5-64; 16), itraconazole (0.015-1; 0.125), terbinafine (0.06->2; 1), caspofungin (8-32; 32), voriconazole (0.015-0.5; 0.25), and posaconazole (0.015-0.25; 0.06 microg/ml), respectively. In conclusion, the MIC50s of these drugs did not exhibit any sign of an upward shift with the exception of fluconazole and tendency cross-resistance between the seven drugs was not observed. We conclude that in vitro resistance to antifungal agents has not significantly changed despite the recent wide-spread use of triazoles for long-term treatment of Cryptococcal meningitis.

Keyword

Antifungal agents; Cryptococcal meningitis; Cryptococcus neoformans; MIC

MeSH Terms

Amphotericin B*
Antifungal Agents
Cryptococcus neoformans*
Cryptococcus*
Fluconazole*
Itraconazole*
Meningitis, Cryptococcal
Triazoles
Amphotericin B
Antifungal Agents
Fluconazole
Itraconazole
Triazoles
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