Lab Anim Res.  2010 Sep;26(3):225-232.

Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats

Affiliations
  • 1Koatech Co., Pyeongtaek, Korea.
  • 2Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University, Daegu, Korea.
  • 3Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea.
  • 4Department of Oral physiology, School of Dentistry and BK21, Kyungpook National University, Daegu, Korea.
  • 5Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, Galveston, USA. ysgwak@utmb.edu

Abstract

Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.

Keyword

Central neuropathic pain; hyperexcitability; rat model

MeSH Terms

Animals
Central Nervous System Sensitization
Discrimination (Psychology)
Neuralgia
Neurons
Posterior Horn Cells
Rats
Spinal Cord
Spinal Cord Injuries
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