Int Neurourol J.  2016 May;20(Suppl 1):S23-S29.

Extracellular Matrix Revisited: Roles in Tissue Engineering

Affiliations
  • 1Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, Korea. kwshin@sogang.ac.kr
  • 2Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Korea.

Abstract

The extracellular matrix (ECM) is a heterogeneous, connective network composed of fibrous glycoproteins that coordinate in vivo to provide the physical scaffolding, mechanical stability, and biochemical cues necessary for tissue morphogenesis and homeostasis. This review highlights some of the recently raised aspects of the roles of the ECM as related to the fields of biophysics and biomedical engineering. Fundamental aspects of focus include the role of the ECM as a basic cellular structure, for novel spontaneous network formation, as an ideal scaffold in tissue engineering, and its essential contribution to cell sheet technology. As these technologies move from the laboratory to clinical practice, they are bound to shape the vast field of tissue engineering for medical transplantations.

Keyword

Extracellular Matrix; Tissue Engineering; Fibronectin; Collagen; Elastin; Cell Sheets

MeSH Terms

Biomedical Engineering
Biophysics
Cellular Structures
Collagen
Cues
Elastin
Extracellular Matrix*
Fibronectins
Glycoproteins
Homeostasis
Morphogenesis
Tissue Engineering*
Full Text Links
  • INJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr