Osteoporos Sarcopenia.  2016 Mar;2(1):25-29.

Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats

Affiliations
  • 1Department of Physical Therapy, Faculty of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan. a.minematsu@kio.ac.jp
  • 2Division of Health Science, Graduate School of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
  • 3Department of Human Behavior, Faculty of Human Development, Kobe University, 3-11 Tsurukabuto, Nada-ku, Kobe, Hyogo 657-8501, Japan.
  • 4Department of Modern Education, Faculty of Education, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
  • 5Department of Physiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Abstract


OBJECTIVES
Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal to high levels of bone mineral density. Bone quality is known to affect bone fragility in T2DM. The aim of this study was to clarify the trabecular bone microstructure and cortical bone geometry of the femur in T2DM model rats.
METHODS
Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n = 5) and Long-Evans Tokushima Otsuka (LETO; n = 5) rats were used. At the age of 18 months, femurs were scanned with micro-computed tomography, and trabecular bone microstructure and cortical bone geometry were analyzed.
RESULTS
Trabecular bone microstructure and cortical bone geometry deteriorated in the femur in OLETF rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular number and connectivity density decreased, and trabecular space significantly increased. Moreover, in OLETF rats, cortical bone volume and section area decreased, and medullary volume significantly increased.
CONCLUSIONS
Long-term T2DM leaded to deterioration in trabecular and cortical bone structure. Therefore, OLETF rats may serve as a useful animal model for investigating the relationship between T2DM and bone quality.

Keyword

Cortical bone geometry; Micro-CT; Otsuka Long-Evans Tokushima Fatty (OLETF) rats; Trabecular bone microstructure
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