Kosin Med J.  2014 Dec;29(2):125-134. 10.7180/kmj.2014.29.2.125.

The Change of Thyroid Stimulating Hormone Values of Healthy Subjects According to Temperature and Aging

• Kim SS
• Lew DH
• Choi JY
• Lee EJ
• Kim MG
• Kim KY
• Kim SK
• Jung JH
• Jung JH
• Hahm JR

• KMID: 2308497
• DOI: http://doi.org/10.7180/kmj.2014.29.2.125

Abstract

OBJECTIVES
We conducted a study to investigate the normal range for TSH and within-individual variations of TSH according to temperature and aging.
PATIENTS AND METHODS
We enrolled patients who underwent periodic medical examinations five times over a six year period (2007.8~2013.6). Anthropometric data and thyroid ultrasonography were evaluated, and serum TSH, T3, and T4 were assayed.
RESULTS
Subjects were 19-64 years old, 120 were female, and 208 were male. Reference ranges for TSH were 0.53-4.94 mIU/L in the first test, 0.49-5.61 mIU/L in the second test, 0.46-6.06 mIU/L in the third test, 0.48-5.99 mIU/L in the fourth test, and 0.52-6.3 mIU/L in the fifth test. When the TSH level was analyzed according to temperature and sex, mean TSH was higher in months in which the average monthly temperatures were below 10degrees C in Jinju, Gyeongnam and female. The aging and low temperatures are associated with increased serum TSH concentrations in the within-individual.
CONCLUSIONS
This study showed that aging is associated with increased serum TSH concentrations in the within-individual and serum TSH concentrations are different in the within-individual according to the temperature.

Keyword

Reference range for TSH; TSH; Variation of TSH

MeSH Terms

Aging*
Female
Gyeongsangnam-do
Humans
Male
Reference Values
Thyroid Gland
Thyrotropin*
Ultrasonography
Thyrotropin

Figure

• 

  Fig. 1 Schematic presentation of enrolled subjects for analysis.

• 

  Fig.2 Estimated marginal means natural logarithm(TSH) 士 SE that was checked five times for six years

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  Fig, 3 Within-individual TSH levels separated by average monthly temperature(10iC) for 146 subjects.

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