Korean J Nephrol.  1997 Sep;16(3):572-577.

A Case of Type I Renal Tubular Acidosis Associated with Graves' Disease and Sjogren' s Syndrome

Affiliations
  • 1Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.

Abstract

Classic distal renal tubular acidosis(type 1 RTA) is a hypokalemic, hyperchloremic metabolic acidosis due to selective defect in distal acidification. Type 1 RTA may be associated with genetic(usually autosomal dominant) or autoimmune disease, drugs and toxin and various tubulointerstitial diseases. This case report describes a 27 year-old female patient with distal RTA, Sjogren' s syndrome and Graves' disease the first case. She had been suffered from muscle weakness and peripheral numbness and was found to have low serum potassium(1.6mEq/L). She was revealed to have 1) distal RTA by NaHCO3 loading test 2) Sjogren' s syndrome by Schirmer' s test and palate biopsy and 3) Graves' disease by exophthalmometry and autoantibody test, thyroid function test. This is the first case as far as I search that report the association of distal RTA, Sjogren' s syndrome, and Graves' disease caused by autoimmune mechanism.

Keyword

Type 1 RTA; Sjogren' s syndrome; Graves' disease

MeSH Terms

Acidosis
Acidosis, Renal Tubular*
Adult
Autoimmune Diseases
Biopsy
Female
Graves Disease*
Humans
Hypesthesia
Muscle Weakness
Palate
Thyroid Function Tests
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