Korean J Nephrol.  2007 Sep;26(5):541-547.

Effects of Spironolactone on the Urinary Excretion of TGF-beta1 in IgA Nephropathy

Affiliations
  • 1Department of internal medicine, College of Medicine, Kyung Hee University. cgihm@yahoo.ac.kr

Abstract

PURPOSE: Transforming growth factor-beta1 (TGF-beta1) has an important role in the pathogenesis of renal damage; it enhances extracellular matrix production. Urinary TGF-beta1 excretion has been shown to be significantly increased in patients with IgA nephropathy. The aim of the present study was to evaluate the effect of spironolactone on urinary TGF-beta1 levels in patients with IgA nephropathy.
METHODS
TGF-beta1 was measured by enzyme-linked immunosorbent assay in random urine specimens from 35 patients with IgA nephropathy. The patients were assigned to a spironolactone group, prednisolone group or losartan group. They were treated over an 8-week period. Urine samples were tested at the beginning and the end of the treatment period.
RESULTS
The patients with IgA nephropathy (n=35) had a higher urinary excretion of TGF-beta1 than normal controls (n=13). Urinary TGF-beta1 excretion was positively correlated with proteinuria and pathological grading but not with serum creatinine. After 8 weeks of treatment, losartan (n=13) and prednisolone (n=11) therapy induced a significant reduction in both urinary protein and TGF-beta1 excretion. After treatment with spironolactone (n=11), urinary protein and TGF-beta1 excretion were decreased. However, the decrease was not statistically significant. There was a significant correlation between the urinary TGF-beta1 excretion and the serum aldosterone (r=0.84; p<0.01); however, treatment with spironolactone abolished this correlation.
CONCLUSION
This study provides evidence that endogenous aldosterone influences urinary TGF-beta1 excretion in patients with IgA nephropathy.

Keyword

Glomerulonephritis; IgA; Transforming growth factor beta 1; Spironolactone

MeSH Terms

Aldosterone
Creatinine
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix
Glomerulonephritis
Glomerulonephritis, IGA*
Humans
Immunoglobulin A*
Losartan
Prednisolone
Proteinuria
Spironolactone*
Transforming Growth Factor beta1*
Aldosterone
Creatinine
Immunoglobulin A
Losartan
Prednisolone
Spironolactone
Transforming Growth Factor beta1
Full Text Links
  • KJN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr