Korean J Hematol.  2007 Sep;42(3):250-257. 10.5045/kjh.2007.42.3.250.

FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. hjoonk@chonnam.ac.kr
  • 2Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.
  • 3Department of Internal Medicine, Chungnam National University College of Medicine, Cheongju, Korea.
  • 4Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
  • 6Department of Hematology/Oncology, Wonkwang University School of Medicin, Iksan, Korea.


BACKGROUND: The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.


FLT3/ITD; Acute myeloid leukemia; Normal karyotype
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