Korean J Hematol.  2007 Sep;42(3):250-257. 10.5045/kjh.2007.42.3.250.

FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. hjoonk@chonnam.ac.kr
  • 2Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.
  • 3Department of Internal Medicine, Chungnam National University College of Medicine, Cheongju, Korea.
  • 4Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
  • 6Department of Hematology/Oncology, Wonkwang University School of Medicin, Iksan, Korea.

Abstract

BACKGROUND: The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.
METHODS
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.
RESULTS
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.
CONCLUSION
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.

Keyword

FLT3/ITD; Acute myeloid leukemia; Normal karyotype
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