Korean J Helicobacter Up Gastrointest Res.  2011 Jun;11(1):26-36. 10.7704/kjhugr.2011.11.1.26.

The Effect of Probiotics for Helicobacter pylori

Affiliations
  • 1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. shimkn@ewha.ac.kr

Abstract

BACKGROUND/AIMS
Helicobacter pylori (H. pylori) infection is a major cause of chronic gastritis and peptic ulcer and a risk factor of gastric malignancy. Antibiotics based H. pylori eradication treatment is 90% effective, however, it is expensive and causes side effects and antibiotics resistance. Probiotics could present a low-cost, alternative solution to prevent or decrease H. pylori colonization.
MATERIALS AND METHODS
Eligible articles were indentified by researches of electronic databases.
RESULTS
In vitro studies demonstrated an inhibitory activity of probiotics on H. pylori growth and that this effect is extremely strain specific. The probiotics seem to be efficacious for the prevention of antibiotics associated side effects and might be of help for the prevention of H. pylori complications by decreasing H. pylori density and gastritis, and for the prevention of H. pylori colonization or re-infection by inhibiting adhesion to gastric epithelial cells. There was no significant evidence that probiotics may increase the H. pylori eradication rate.
CONCLUSION
Probiotics could be an accessory treatment for H. pylori related gastric diseases, but more researches will be needed.

Keyword

Helicobacter pylori; Probiotics

MeSH Terms

Anti-Bacterial Agents
Colon
Electronics
Electrons
Epithelial Cells
Gastritis
Helicobacter
Helicobacter pylori
Peptic Ulcer
Probiotics
Risk Factors
Sprains and Strains
Stomach Diseases
Anti-Bacterial Agents
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