Korean J Gastrointest Endosc.  2006 May;32(5):342-346.

A Case of Gastric Syphilis Mimicking Advanced Gastric Cancer

  • 1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, Seoul National University, Bundang Hospital, Seongnam, Korea. dkree@snubh.org
  • 3Department of Pathology, Seoul National University, Bundang Hospital, Seongnam, Korea.


Gastric syphilis has been reported to be relatively rare due to the difficulty in making a histological diagnosis. However if a serologic test for syphilis is positive and the ulcer regresses after anti-syphilitic treatment, it can be assumed that the gastritis was caused by Treponema Pallidum. The clinical diagnosis of gastric syphilis ranges from a benign ulcer to mimicking an infiltrative carcinoma or lymphoma. We encountered a 21-year-old woman who was referred for linitis plastica with epigastric pain and weight loss. The gastroduodenoscopy revealed multiple irregular gastric mucopurulent shallow ulceration and several nodular lesions mimicking linitis plastica. The appropriate antibiotic treatment resulted in a dramatic improvement and a complete reversal of gastric lesions. This recent case of gastric syphilis emphasizes the importance of remaining alert to the manifestations of syphilis.


Gastric syphilis; Treponema Pallidum; Linitis plastica
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